Wharton lab
Exploring Key Pathways and Interventions to Reduce Alzheimer's Disease Risk
Areas of Investigation
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Understanding the contribution of midlife vascular risk factors in AD and developing interventions to target the most relevant AD biomarkers including AD-related brain changes, inflammation, sleep, and heart health, in individuals at high risk for AD.​​​
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Testing whether certain blood pressure medications penetrate the brain and act on Alzheimer's disease biomarkers, thereby potentially reducing AD risk.​
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​Testing potential racial differences in the way that blood pressure medications penetrate the brain and potentially influence AD risk, while at the same time investigating both physiological and sociological factors that may lead to these differences.​
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Understanding how sex hormones in the body and in the brain influence an individual’s risk for AD.​
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​Adapting existing AD caregiver interventions to make the information more applicable to African Americans and the LGBTQ community.
A Message of Appreciation
We are tremendously grateful to our research participants and our community volunteers, whose invaluable contributions have made our research possible! Your willingness to engage and share your experiences has provided us with essential insight. Thank you for being an integral part of this journey and for helping us advance our understanding in meaningful ways!